The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status

The bone marrow of myeloma patients is steadily inhabited by a normal-sized pool of functional regulatory T cells irrespectiveof the disease status

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Conflicting data have been reported about the frequency and function of regulatory T cells in multiple myeloma.Most studies have investigated peripheral blood rather than bone marrow Tregs and side-by-side comparisons with bone marrow from healthy donors have still not been made.In this study, we show that regulatory T-cells total count, subset distribution, and expression of chemokine receptors are similar in the bone marrow of myeloma patients and healthy donors.Regulatory T altruria cabernet sauvignon cells are not recruited by myeloma cells in the bone marrow and their counts are unaffected by the tumor burden and the nemacor maxx disease status.

The diversity of T-cell receptor repertoire is highly preserved ensuring broad reactivity and effective suppressor function.Our results indicate that regulatory T cells may not be the main players of immunological tolerance to myeloma cells under base-line conditions, but their fully preserved immune competence may promote their inadvertent activation and blunt T-cell driven anti-myeloma immune interventions even after myeloma cells have successfully been cleared by chemotherapy.